Endocrine Abstracts

Introduction: Empirical research studies suggest that continuous glucose monitoring systems (CGMS) are safe and could optimize neonatal hypoglycaemia management. However, they need to be tested within resource-limited, time-constrained clinical practice. CGMS was piloted in our Level 3 Neonatal Intensive Care Unit (NICU) in June 2017. Five key barriers to its effective implementation were identified: 1) Lack of NICU staff confidence in device usage 2) Infant discomfort during ...

Type 2 diabetes is a metabolic disorder characterised by insulin resistance and is associated with diminished signalling through the insulin receptor. Protein tyrosine phosphatase 1B (PTP1B), encoded by the PTPN1 gene, has been shown to attenuate insulin’s actions by de-phosphorylating the activated insulin receptor and downstream signalling components such as IRS1. Several studies have highlighted PTP1B as a potential therapeutic target for type 2 diabetes and obesity; h...

Uterine involution is a critical component of postpartum reproduction, which involves endometrial tissue repair, myometrial contraction and bacterial clearance. The uterus synthesises insulin-like growth factors (IGF-I and –II), IGF-I receptor (IGF-1R), and IGF binding proteins (IGFBPs -1 to -6) that regulate IGF bioavailability. This study used tissue from 12 multiparous Holstein-Friesian cows at day 14 postpartum to investigate expression of the uterine IGF system durin...